Leonard: This is silly. I have nothing to worry about.
Sheldon: Oh, I don't know. I mean, statistically speaking, I'm sure you have something to worry about.
Leonard: What do you mean?
Sheldon: Well, if we assume your looks are average, right off the bat fifty percent of men on Earth are more attractive than you. That's 1.5 billion handsome lads standing by, waiting to rain on your parade.
Leonard: Well, yeah, but this isn't just about looks. I'm way above average in a lot of other things.
Sheldon: Not height, vision, athleticism or ability to digest dairy products.

Sheldon: I'm not saying you don't have attractive qualities. Your choice of friends is impeccable, you're a good sleeper, and last but not least, you buy the grapes I like. You're a real catch compared to some snoring guy with a fridge full of lousy grapes.

Howard: When I was starting to do magic in junior high, I thought I could be an escape artist like Harry Houdini.
Raj: How did that work out?
Howard: Pretty good. I managed to escape friends, popularity, and every party thrown in a twelve mile radius.

Raj: What are you drawing over there?
Sheldon: It's a hypothetical containment field for a Frisbee-sized wormhole that could serve as a portal to a parallel universe.
Howard: Oh, you silly doodlebug.
Leonard: You know, a lot of scientists believe that making contact with other life-forms would probably not end well for us.
Sheldon: It's a Frisbee-sized wormhole, Leonard. You can block it with a Frisbee. Calm down.

Raj: Ooh, this is exciting. Like one of my classic murder mystery dinner parties.
Leonard: Right, the case of who murdered three Saturday nights of my life?
Howard: Colonel Koothrappali in the kitchen with the olive spread.
Raj: It was tapenade and you guys suck.

Leonard: Who are you talking to?
Penny: Oh, just this guy I met at school.
Leonard: oh, great. We're still dating, right?
Penny: Relax. He's just a friend. We're doing an oral report together. He's really nice.
Leonard: I'm sorry, what was that? I had a little stroke after oral.

Penny: Look, he just moved here from London, okay? He doesn't really know anybody.
Leonard: Oh, good, an English accent, the sexiest accent you can have.
Penny: No, that's not true. There's French, there's Italian. No, you're right, it's the best.

Penny: What am I supposed to say?
Leonard: Say "Can't talk right now, hanging with my boyfriend. England sucks. You suck. USA number one."

Amy: You think that's bad? In college, I passed out at a frat party and woke up with more clothes on.

Amy: Well, at least when we do make love, Sheldon won't be thinking about his mother. And yes, that is a cleverly veiled reference to Howard's lifelong obsession to crawl back into her spacious womb.

Mrs. Wolowitz I'm not going near that fakakta thing. I'll catch a computer virus.
Howard: You can't catch a computer virus.
Mrs. Wolowitz Oh, so now you're an astronaut and a doctor?

Mrs. Wolowitz: Wives don't take boys from their mothers.

Mrs. Wolowitz: Howard, help, my hand's stuck in the garbage disposal.
Howard: Let go of whatever piece of food you're holding.
Mrs. Wolowitz: Are you kidding? It's a perfectly good chicken leg.

Mrs. Wolowitz Oh please. You're a tall glass of brown water. Have dessert.

Wil Wheaton: No offence, but I've been acting since I was a kid. I think I can handle a web show without a lot of direction.