Wil Wheaton: Did you ever consider that maybe Arthur would be happy to know that his show has outlived him?
Sheldon: I doubt it. He was kind of a mean old crank.

Raj: I thought you were boycotting Wil's show.
Sheldon: I was, but I decided to give it a shot, and I actually enjoyed it. Just out of curiosity, how did you come to be on the show? Did he ask you? Did you ask him? Did you just show up on the set and ring that doorbell?
Howard: Sheldon, if you want to be on the show, you're gonna have to apologize to Wil.
Sheldon: That would be the mature thing to do. Let's put a pin in that and keep thinking.

Amy: The university has been throwing money at my study. With any luck, there'll be a brain disease with my name on it.
Bernadette: Fingers crossed.
Amy: Which is ironic, because if you had Fowler's palsy, you wouldn't be able to cross your fingers.

Howard: You don't even have a license.
Sheldon: Actually, I do.
Howard: Really? Since when?
Sheldon: Three years ago. I went on a bit of a license kick. I'm also a commercial fisherman.

Leonard: How about you?
Howard: Oh, that depends on whether I tell Bernadette or not.
Bernadette: Howard, I can hear you. The baby monitor is on.
Howard: I know. I was joking. I'm gonna put it in a college fund. (Mimes saying no)

Penny: All right, just give her some space, all right? Don't call, don't text, don't e-mail.
Raj: That's crazy. What if I see a sunset that reminds me of her?

Sheldon: But I need it. It's the only way to settle the contradictions between gravity and quantum mechanics.
Penny: Well, it's too much money, you can't ask for that all at once.
Sheldon: Well, what if I ask for it in six easy installments of $83,333,333.33?

Amy: I don't want to be in the middle of this. No matter which way I vote, I'm either a bad friend, a bad fiancée, or an ungrateful recipient of a battery.
Sheldon: Next time I have a meeting in the shower, you're welcome to attend.
Amy: Sheldon. Sheldon for president. I pick Sheldon!

Bernadette: Should he be saying that?
Raj: Uh, probably not.
Howard: Yeah, this is public radio. Doesn't he realize that dozens of people might hear him?

Wil Wheaton: [on TV] It's time for Professor Proton's science joke of the day. Why can you not trust atoms?
Sheldon: Hmm.
Wil Wheaton: [on TV] Because they make up everything.
Sheldon: Oh, that's funny! Yeah, because they do. They make up everything.

Sheldon: Well, luckily, I got the number of the company who's trying to reboot the show, so I need you all to call and register your displeasure.
Raj: Sheldon, no one's gonna do that.
Sheldon: Not true. I know of three calls they've received already: a Southern gentleman, um, a Cockney chimney sweep, and, uh, Mr. T, hmm? Who - spoiler alert - pities the fool who tries to reboot that show.

Leonard: What about tiresome lunatic with a bad haircut? Has he called yet?

Sheldon: Some news of our wedding. I have sent you all a "save the date" e-mail.
Penny: Oh, exciting. You guys picked a date?
Sheldon: Better. I picked 80 dates. And I need you to save them all until we narrow it down.

Sheldon: I got you a little something to help you relax.
Amy: Sheldon, that is the sweetest, most- What what is this?
Sheldon: The notes from our quantum cognition project. I thought we could spend the evening grinding away on it.
Amy: (sighs) I just got home, I'm tired.
Sheldon: Of Howard, I know. So how about you and me make some beautiful science together?
Amy: Sheldon, I want to work on this with you, just not tonight. What if we get up early and do it in the morning? I promise, I'll be way more into it.
Sheldon: You know what? There was a time that you would've been happy to stay up and collaborate all night with me. And then wake up in the morning and do it some more.
Amy: (sighs) Fine, but can we make it quick?
Sheldon: No. If you're just gonna make me do all the work, then go to bed. But don't be surprised if you walk out here and catch me doing it myself.

Penny: What's up?
Beverly Hofstadter: Well, I enjoyed our conversation the other day, and I was hoping to continue it.
Penny: Really?
Beverly Hofstadter: Uh, yes. You may find this surprising, but I don't have a lot of what you would call girlfriends.
Penny: (exaggerated) What?
Beverly Hofstadter: Of course, there are my female colleagues, but, uh, they're all Freudians, so the only boy that I can dish about is my father. (chuckles)