Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Kripke: Was she naked or was she wearing lingerie?
Sheldon: I didn't notice.
Kripke: How could you not notice?
Sheldon: i was too busy squishing all the desirable parts of her body.
Kripke: Ah, you're killing me, Cooper!

Leonard: What?
Amy: Sheldon has something he'd like to say.
Sheldon: I'm sorry I didn't react appropriately. You and Penny are bringing new life into the world. Congratulations. I can't wait to meet it.
Leonard: "It"?
Sheldon: That's a gender-neutral pronoun. If you're offended, take it up with the English language.

Leonard: That's not what she's doing, Leslie. She's just trying to shore up her self esteem. It has nothing to do with sex.
Leslie: Everything has to do with sex.
Howard: Mmmm, testify. (Raises his hand for a high-five)
Leslie: I'm not touching that.

Mary Cooper: Thank you, God, for the food we are about to receive and for the nourishment of our bodies and bless the hands that prepared it. Amen.
Sheldon: Given that your hands prepared it, isn't that a little self-serving?
Mary Cooper: You start changing the words to the prayers, next thing you know, you're in a church with a guitar.